tPA for acute ischaemic stroke

Clinical pearls

  1. NNT 8 patients for 1 patient to benefit (improved function in 3 months)
  2. Risks
    1. 10 times more likely to have a risk of ICH
      • RF for ICH if:
        1. baseline NIHSS score >20
        2. age >70
        3. ischemic changes on CT
        4. glucose >16.7mmol/l
    2. <5% risk of developing an allergic reaction

Summary of studies

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